Cobimetinib / XL-518 CAS:934660-93-2

Cobimetinib / XL-518 CAS:934660-93-2
Product Details

Product Information

CAS NO.934660-93-2 
Product NameCobimetinib
SynonymsXL-518;GDC-0973
FormulaC21H21F3IN3O2
Molecular Weight531.31
Spec / Purity98%min
Supply Capacity
DetailsCobimetinib (GDC-0973, XL-518) is a MEK inhibitor being . It is being studied in combination with BRAF inhibitors to treat several cancers. Early data showed that administration of Cobimetinib in combination with the BRAF inhibitor vemurafenib increased progression-free survival in melanoma patients with a BRAF V600 mutation by 3.7 months compared to vemurafenib alone. Phase 3 clinical trials are ongoing and expected to complete by 2017. After good results in 2014 the combination has been submitted to EC and FDA for marketing approval.


 

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